The will kick off their title defense against a team that has their own Super Bowl aspirations. The Rams will host the in the NFL's season-opening game on Thursday, Sept. 8.Buffalo is a formidable season-opening opponent for Los Angeles. Led by quarterback , the Delon Wright Jersey Bills have made the playoffs each of the past three years and have won the last two AFC East division titles. Buffalo has advanced beyond the AFC wild card round the past two seasons before having their seasons ended by the . Buffalo and Kansas City dueled in an epic playoff game this past January that wasn't decided until game-winning score le s than five minutes into overtime.Looking to slow Allen and the Bills' offense down is a Willie Cauley-Stein Jersey Rams defense that is led by three-time Defensive Player of the Year . Led by Donald and cornerback , the Rams' defense shut out and the ' high-octane offense for the final 25 minutes of Super Bowl LVI. Speaking of last year's Super Bowl, , who recorded two sacks of Burrow in the Rams' 23-20 win, will face his former teammates in Week 1 Luka Doncic Jersey after signing with the Bills this past offseason.Here's a look at each Week 1 matchup: Buffalo Bills at Los Angeles Rams (Sept. 8, 8:20 p.m. ET) at (Sept. 11, 1 p.m. ET) at (Sept. 11, 1 p.m. ET) at (Sept. 11, 1 p.m. ET) at Cincinnati Bengals (Sept. 11, 1 p.m. ET) at (Sept. 11, 1 p.m. ET) at (Sept. 11, 1 p.m. ET) at (Sept. 11, 1 p.m. ET) at Josh Reaves Jersey (Sept. 11, 1 p.m. Josh Richardson Jersey ET) at (Sept. 11, 1 p.m. ET)Kansas City Chiefs at (Sept. 11, 4:25 p.m. ET) at (Sept. 11, 4:25 p.m. ET) at (Sept. 11, 4:25 p.m. ET) at (Sept. 11, 4:25 p.m. ET) at (Sept. 11, 8:20 p.m. ET) at (Sept. 12, 8:20 p.m. ET)